Corpse Killer is a full-motion video shoot-'em up. You play as an elite special forces soldier, who parachutes onto a remote tropical island. It seems the evil genius Dr. Hellman has found a way to raise the dead, and created an island of zombies. It's up to you to shoot your way through the undead hordes and stop Dr. Hellman. The game is played from a first-person perspective. Various zombies pop up in front of a video background, and you shoot them down by moving a cursor on screen or by using a light gun. The Saturn version has a few different features including extra power-ups as well as added footage of enemies.

An unnamed United States Marine is airdropped onto a tropical island on a top secret mission to stop the evil Dr. Hellman, who plans to release his army of zombies on the world. He is bitten by a zombie and also meets an attractive female reporter and a Rastafarian male driver. Four of the marine lieutenant's comrades are captured by Hellman and turned into zombies. To rescue them, the lieutenant infiltrates Hellman's compound and shoots each of them with bullets coated with extract from Datura plants, which can turn freshly-created zombies back into humans.