The earth is overpopulated and mankind must find a second home. The spaceship Amazon is sent to investigate Saturn and Jupiter for possible colonization. Near the end of its mission, all contact is lost with the ship except for a distress beacon. The player is part of the crew sent to the Amazon's last known location to find out what happened. Creature Shock is a first-person shooter with Full Motion Video and arcade-like elements. Aliens of all sizes and types will try to destroy the team, but each one has a weak point that can be exploited. The fighting takes place on the surface of asteroids and within mazes of passageways underground. There are also two 3D sections where the player gets to pilot the ship.

In 2123, the UNS Amazon is sent as part of an exploration fleet to various planets to determine new viable locations for settlement as the Earth is destroyed by human activity. En route to Saturn, the Amazon is ensnared by a massive alien being resembling a large asteroid. The protagonist, Commander Jason Barr, is sent to investigate the incident.