Alien³ was released after the Alien 3 film. After success on the Super Nintendo and Genesis platforms, the game was built and ported to other systems, including the Commodore 64 and Game Gear. The game is set on the world of the film, Fury 161, but the gameplay has more in common with the film Aliens, throwing wave after wave of enemies at the player.

Loosely based off of the movie franchise, the main character Ripley arrives at Fiorina "Fury" 161, and she finds the planet is infested by Xenomorph Runnera. She is equipped with Colonial Marine equipment to defend herself while rescuing prisoners that are captured by the Aliens.