In Via Domus, players control Elliott Maslow, another survivor of the Oceanic flight 815 plane crash. The game takes place during the first 70 days after the crash and includes all of the main characters from the show.

Oceanic Flight 815 out of Sydney, Australia, is mysteriously brought down out of the sky, crashing on an uncharted island somewhere in the Pacific Ocean. The survivors quickly learn they must band together in order to have any hope of rescue, because the island is treacherous and holds many secrets. As they are about to learn, the survivors have secrets of their own... Like the other castaways, out leading character has a tortured past that has brought him to the island, and he must redeem himself to find a way home. He suffers from amnesia and needs to find out who he is through playable flashbacks, interacting with the other castaways, and exploring the island.