Crash of the Titans is the sixth Crash Bandicoot series game. The gameplay has the player explore levels, picking up power-ups to use against enemies as well as for the first time, use fighting combos such as punches and kicks against enemies. When Crash defeats an enemy or destroys an object, a magical substance known as Mojo is released. If the player collects enough Mojo, he will earn either an ability upgrade or a new move.

The game's story centers on the discovery of a substance known as Mojo, which Doctor Neo Cortex plans to use to turn the inhabitants of the Wumpa Islands into an army of loyal mutants known as Titans. Crash Bandicoot must stop Cortex by using the technique of jacking to take control of and destroy Cortex's Titans while collecting the mojo.