Players will once again assume the role of the New Kid, and join South Park favorites Stan, Kyle, Kenny and Cartman in a new hilarious and outrageous adventure. This time, players will delve into the crime-ridden underbelly of South Park with Coon and Friends. This dedicated group of crime fighters was formed by Eric Cartman whose superhero alter-ego, The Coon, is half man, half raccoon. As the New Kid, players will join Mysterion, Toolshed, Human Kite, Mosquito, Mint Berry Crunch and a host of others to battle the forces of evil while Coon strives to make his team the most beloved superheroes in history.

After the events of South Park: The Stick of Truth, the children of South Park become role-playing superheroes. However, a falling-out over Cartman's planned film franchise splinters the boys split into two groups, with some calling for a civil war to make their own franchise. The player again controls The New Kid, though they can now change his gender to female if they wish.