The Great Giana Sisters is a side-scrolling platform game originally released in 1987 for various home computers. Players control Giana, navigating through levels filled with enemies, hazards, and hidden items. The goal is to reach the end of each stage by jumping across platforms and avoiding obstacles. Power-ups, such as the ability to break blocks or shoot projectiles, aid in progression. The game is known for its strong resemblance to Super Mario Bros. in both gameplay and design.

Giana is suffering from a nightmare she has to travel through 32 levels filled with monsters. You are looking for your sister Maria who, after you defeated the final boss, wakes you up from your terrible dream.