The House of the Dead 4 is a light gun arcade game with a horror theme and the fourth installment of the House of the Dead series of video games, developed by Sega. The game takes place between the events of The House of the Dead 2 and The House of the Dead III, and introduced several new gameplay concepts. Players can control characters James Taylor, from The House of the Dead 2, or Kate Green, a new character to the series. The House of the Dead 4 is the first game to run on the Sega Lindbergh arcade system board. A PlayStation 3 version featuring support for PlayStation Move and the two stages from The House of the Dead 4 Special was released on April 17, 2012 on the PlayStation Network.

In 2003, veteran AMS agent James Taylor and rookie Kate Green gather intelligence at the fifth basement floor of the AMS' European headquarters. James suspects that the events of the 2000 Goldman case have not ended. A sudden earthquake rocks the room, collapsing the basement walls and trapping the agents. Several days later, while awaiting backup, James' PDA goes off; hordes of creatures appear on the security cameras. James and Kate arm themselves and escape. In a classified information room, they uncover a plot to fire nuclear missiles worldwide within 24 hours' time.