Lux-Pain is a visual novel-type adventure video game developed by Killaware and published by Marvelous Entertainment for the Nintendo DS. The game was released in Japan on March 27, 2008. It was published in North America by Ignition Entertainment on March 24, 2009, and in Europe by Rising Star Games on March 27, 2009.

Lux-Pain is set in the historical Kisaragi City, a town plagued by mysteries from small mishaps to murders - with no logical explanation as to why these events occur. It seems "Silent", a worm born through hate and sadness, has infected humans and forced them to commit atrocious crimes. Atsuki's parents are the victim of such crimes. To avenge his parents, Atsuki goes through a dangerous operation to acquire Lux-Pain in his left arm, a power so strong that it turns his right eye golden when using it to seek and destroy Silent for good.