An experiment at a secret research facility has gone catastrophically wrong. Daniel Lamb and Leo Kasper are the only surviving subjects. The Pickman Project will stop at nothing to hunt them down and stop the truth from getting out. Demented screams echo around the dank asylum that has caged you for the last six years. You open your eyes. A white-coated body slumps to the floor through your shaking hands. A bloody syringe slips from your arm. Waves of confusion and paranoia crash over you. You have no idea who you are or how you got here. The door to your cell is open. One choice. One chance. They took your life. Time to take it back.

During a severe lightning storm, the security systems at the Dixmor Asylum for the Criminally Insane go offline, allowing inmates Daniel Lamb and Leo Kasper to escape. Daniel is disoriented and amnesiac, unable to remember anything about himself. Under Leo's guidance, he makes his way back to the ruins of his old home, which is located nearby. Inside, Daniel recovers drugs which help to clear his head, and discovers hints about the details of his former life. He and Leo follow a series of clues to unravel the secrets of Daniel's past, killing anyone who interferes; along the way, they are pursued by bounty hunters and agents of a mysterious organization called "the Project".