Cashand Case is a mystery and investigative game, in the visual novel style, where the player is a detective hired to investigate the murder of a mobster head of a wealthy family during the 60's. The main idea of the game is to investigate the mansion and surroundings, where the player must look for clues, solve puzzles and talk to suspects. With each passing day, another murder can happen and the number of leads may increase as well.

The game begins with the protagonist being taken to the family's attorney's office, Mr Sheppard, and then to the Cashand family mansion, where the murder took place. On the spot, Sheppard presents the scene, the characters suspected of the crime and some notions of gameplay to the player.